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Fields of Research
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The laboratories at the Hospital conduct both clinical testing and research. All experimental protocols are reviewed prior to use by the Institutional Review Board.
Fields of research include genetic factors in personality disorders, Alzheimer's and Parkinson's disease, osteoporosis, schizophrenia, and Attention Deficiency and Hyperactivity Disorder (ADHD).
Herzog Hospital has received several grants from the National Institutes of Mental Health and NARSAD (National Alliance for Research into Schizophrenia and Allied Disorders) rarely awarded outside the U.S. It also has a widely recognised laboratory specializing in research into the brain of rats.
The Alzheimer's research laboratory has received recognition from the European Commission and the Israeli Ministry of Science.
Herzog Hospital performs drug research on behalf of several international pharmaceutical companies.
SARAH HERZOG HOSPITAL - RESEARCH PROJECTS
Genetics
* The effect of ethnicity on allelic frequency of common genetic polymorphisms
Genetics of Normal & Abnormal Behavior, Including Psychosis, Learning Disabilities & Violence
Learning Disabilities. Conduct Disorder & Violence in Children Joint projects with– University of Toronto and Harvard University
Genetics of Personality – genetics of addiction- smoking, drugs
Executive Function – Alzheimer’s and other dementias
Genetic Risk Factors of Susceptibility to Stress and Trauma
Genetic Study of Personality and Eating Habits
Psychiatry
Neuropsychological evaluation of attention and concentration deficits in schizophrenia
The development of new methods of diagnosis and classification of schizophrenia with special focus on negative symptoms and cognitive deficits
Studies of the role of genetic polymorphism in schizophrenia using novel family study methods
The assessment of correlations between clinical status and serum levels of long-acting antipsychotic compounds
Assessment of serum free radicals levels and their role in the pathogenesis of schizophrenia and tardive dyskinesia ( movement disorder induced by psychiatric drugs)
The role of central nervous system excitaory amino acids (EAAs) neurotransmission in the pathophysiology of schizophrenia and related psychiatric syndromes
Investigations of the safety and efficacy of the NMDA receptor modulators glycine and d-cycloserine as potential new treatments in schizophrenia and related psychiatric syndromes
Assessment of the correlation between NMDA receptor polymorphism and treatment response to glycine and d-cycloserine
Efficacy and safety of novel atypical antipsychotics (i.e. clozapine, risperidone, olanzepine, iloperidone).
A new biofeedback modality for the treatment of Attention Deficit Disorder (ADD)
Cognitive Processing without Awareness in Hypnosis, Electrophysiological Manifestations.
The effects of family attitudes upon the course of illness of schizophrenic patients.
Nutrition and Brain Function in Psychiatry and Geriatrics including Alzheimer’s and Parkinson’s Disease
Animal models of schizophrenia and tardive dyskinesia based upon the PCP/NMDA hypothesis of schizophrenia and the glutamatergic hypothesis of tardive dyskinesia
The role of EAAs in the etiology of brain damage
The assessment of glycine and d-cycloserine-induced morphological changes in rat brain.
Effects of nutritional iron deficiency on hippocampal development in relation to cognitive behavior in rats
Manipulations of endogenous iron and neurotoxicity induced by excitatory amino acids in rat brain.
Combination of diet restriction and antioxidant drugs for protection from Parkinson’s disease
High dose glycine nutrition affects glial cell morphology in rat hippocampus and cerebellum
Diet Restriction Increases Enkephalin-and Dynorphin-like Immunoreactivity in Rat Brain and Attenuates Long-term Retention of Passive Avoidance
Neurogeriatrics
Age Associated Cognitive Decline
Posterior Truncal Tacile Extinction in Anteriorly Flexed Parkinsonian (PD) Patients
Early Detection of Alzheimer’s Disease by Deficits in Autonomic Activity and Internal
Cognition
Biofeedback therapy of agitation instead of pharmacological treatment in patients with
Alzheimer’s disease
Effect of overt orienting in a visual scene on memory in Alzheimer patients
Category-specific semantic deficit in Anterior thalamic infarction
Survey of the age structure of “age relevant” articles in four general medical journals
Prevalence of potentially reversible dementias and actual reversibility in a memory
clinic cohort
Joint Israel-Canada enteral feeding study of end stage dementia patients
Psychotrauma
Genetic factors in the prevalence of post traumatic stress disorder
The wellbeing of Holocaust survivors born during the war
Prevention of the effects of trauma resulting from traffic accidents
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